Montelukast 4 mg + Levocetirizine 2.5 mg Suspension
Montelukast is a leukotriene antagonist. It binds with high affinity to the LTD4 receptor inhibiting bronchoconstriction. Crysteinyl. Leukotrienes (LTC4, LTD4, LTE4) are important pro inflammatory. Mediators in asthma and also they have been correlated with the physiology of asthma.
Prophylaxis and treatment of asthma. Aspirin Induced asthma.
It should not be abruptly, substitute for inhaled or oral corticosteroids.
Churg- strauss syndrome, angioedema and skin reactions.
Phenytoin rifampin and carbamazepine, decrease the plasma concentration of montelukast.
Adults 10 mg tab OD
Children : 6-14 years 5 mg od, 2-5 years 2 mg od.
Levocetirizine diyar ochloride is a new generation non sedative long acting H1 receptor antagonist antihistamine with less side-effects compared with other antihistamines. It is a selective peripheral H1 receptor antagonist.
Seasonal allergic rhinitis, perennial allergic rhinitis, ocular symptom (such as redness, lacrimation and itching.) Chronic idiopathic urticaria, dermographism, atopic eczema and contact dermatitis, acute allergic reactions due to drugs.
Hypersensitivity to levocetirizine or to any piperazine derivative, patient with severe renal impairment.
Patient involving to drive/ operate machine, concurrent use with alcohol.
Headache, somnolence, dry mouth, fatigue, rhinitis, pharyngitis, asthenia, abdominal pain, migraine, GI disturbances, mild drowsiness.
The extent of absorption of other CNS depressants may have effects on the CNS.