Montelukast 10 mg + Fexofenadine 120 mg Tablet
Montelukast 10 mg
Montelukast is a leukotriene antagonist. It binds with high affinity to the LTD4 receptor inhibiting bronchoconstriction. Crysteinyl. Leukotrienes (LTC4, LTD4, LTE4) are important pro inflammatory. Mediators in asthma and also they have been correlated with the physiology of asthma.
Prophylaxis and treatment of asthma. Aspirin Induced asthma.
It should not be abruptly, substitute for inhaled or oral corticosteroids.
Churg- strauss syndrome, angioedema and skin reactions.
Phenytoin rifampin and carbamazepine, decrease the plasma concentration of montelukast.
Adults 10 mg tab OD
Children : 6-14 years 5 mg od, 2-5 years 2 mg od.
Fexofenadine 120 mg
Selective H1 antagonist good GI absorption. Excretion mainly in bile, little in urine.
Allergic rhinitis, Allergic skin disorders.
Prescribe to pregnant women only if potential benefit out weight the potential risk to foetus, lactation.
Fatigue, headache, drowsiness, dyspepsia, nausea.
Ketoconazole and erythromycin inhibit the metabolism and increase plasma concentration.
120mg – 180mg once a day