Zoynim-P Tablet

Nimesulide 100mg+ Paracetamol 325 Tablet

Zoynim P

Zoynim-P Tablet

Nimesulide 100mg+ Paracetamol 325 Tablet

Nimesulide 100mg+ Paracetamol 325 Tablet Nimesulide Non steroidal anti-inflammatory drug with minimal gastric side effects has some selectivity for Cox-2 than Cox-1. In addition to inhibition of prostaglandin synthesis, It also reduces generation of superoxide by neutrophils, inhibits PAF synthesis, inhibits TNE and inhibits proteinase activity in cartilage, thus preventing breakdown of osteoarthritic human cartilage. […]

MRP : Rs.36/10tab

Package : 10x20 Blister

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Product Description

Nimesulide 100mg+ Paracetamol 325 Tablet

Nimesulide

Non steroidal anti-inflammatory drug with minimal gastric side effects has some selectivity for Cox-2 than Cox-1. In addition to inhibition of prostaglandin synthesis, It also reduces generation of superoxide by neutrophils, inhibits PAF synthesis, inhibits TNE and inhibits proteinase activity in cartilage, thus preventing breakdown of osteoarthritic human cartilage.

Indications

Osteoarthritis, dysmenorrhoea, rheumatoid, arthritis, low back pain, dysmenorrhoea, dental pain, post operative pain, trauma.

Contraindications

GI bleed, peptic ulcer, hepatic dysfunction, pregnancy, lactation.

Safety Profile

Reduce dose in elderly, renal dysfunction, heart failure.

Adverse Effects

Epigastralgia, heartburn, nausea, loose motions, rash, pruritus, somnolence, dizziness.

Dosage

100 mg twice a day. Children: 5 mg/kg/day in two or three divided dose.

Paracetamol

Paracetamol is a valuable central analgesic. It acts on CNS to produce analgesic effects. It has negligible anti inflammatory action in therapeutic dose. It does not stimulate respiration, alter acid base balance, causes less gastric irritation, have no effect on cellular metabolism or clotting factors, it is not uricosuric.

 

Indications

Pain, fever

 

Contraindications

Analgesic nephropathy.

 

Safety Profile

Renal and hepatic impairment.

 

Adverse Effects

Epigastric distress, nausea, rashes, leukopenia is rare.

 

Dosage

Adults : 0.5-1.0gm. 3-6 times daily maximum 4gm.

Children : 15mg/kg/dose or 60 mg/kg/24 hours divided every 6 hours. Maximum 5 doses SOS (each dose -0-0 months – 40mg, 4-11 months -80mg, 1-6 years 120-240 mg., 6-12 years 220-480mg. Max. 5 doses/24 hours.)