Esomet-DSR Capsule

Esomeprazole 40 mg+ Domperidone 30 mg SR Capsules

Esomet DSR

Esomet-DSR Capsule

Esomeprazole 40 mg+ Domperidone 30 mg SR Capsules

Esomeprazole 40 mg+ Domperidone 30 mg SR Capsules Esomeprazole 40 mg It is a proton pump inhibitors that suppresses gastric acid secretion by specific inhibition of the H+/K+ ATPase in the gastric parietal cell. Indications Gastroesophageal reflux disease. Eradication of Helicobacter pylori in combine with appropriate antibacterial regimens. Healing and maintenance of erosive oesophagitis.   […]

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Package : 10x10 Alu-Alu Tablet

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Product Description

Esomeprazole 40 mg+ Domperidone 30 mg SR Capsules

Esomeprazole 40 mg

It is a proton pump inhibitors that suppresses gastric acid secretion by specific inhibition of the H+/K+ ATPase in the gastric parietal cell.

Indications

Gastroesophageal reflux disease. Eradication of Helicobacter pylori in combine with appropriate antibacterial regimens. Healing and maintenance of erosive oesophagitis.

 

Contraindications

Hypersensitivity to any component of the formulation.

Safety Profile

Reduced dose in hepatic insufficiency. Should be taken one hour before meals.

Adverse Effects

Headache, flatulence, Dry mouth, alkaline phosphatase.

Drug Interactions

Esomeprazole may interfere with the absorption of drug where gastric PH is an important determinant of bioavailability e.g. ketoconazole, iron salts and digoxin.

Dosage

Gastroesophageal reflux disease, healing of erosive esophagitis: 20 mg or 40 mg once daily for 4 to 8 weeks. Maintenance of healing of erosive oesophagitis: 20 mg once daily. Symptomatic gastroesophageal reflux: 20 mg once daily for 4 weeks. H-pylori eradication to reduce the risk of duodenal with amoxicillin, 11g twice daily and clarithromycin 500 mg twice daily for 10 days.

Domperidone 30 mg

Powerful dopamine antagonist having antiemetic activity. It increases gastric emptying and shortens the stay of liquids. Semisolids and solid in the stomach.

Indictions

Acute nausea and vomiting, reflux oesophagitis. Dyspepsia, Peptic ulcer, uremia.

Contraindications

GI obstructions of perforation epilepsy, pheochromocytoma, extrapyramidal symptoms.

Safety Profile

Beneficial effects of domperidone may be antagonised by anticholinergic drug. Renal impairment.

Adverse Effects

Galactorrhoea in females and gynaecomastia in males due to increased production of prolactin.

Drug Interactions

Digoxin: Decreased absorption of digoxin, Aspirin, Paracetamol and oral diazepam: Increased absorption of these drugs. Anticholinergic drug: Effect of domperidone antagonised. Phenothiazines: Increased CNS depression.

Dosage

10-20 mg every 4-8 hours. Children 0.3 mg/kg body weight 3-4 times daily. Before meals and bedtime.