Description

Nimesulide 100mg Mouth Dissolving Tablet

Nimesulide

Non steroidal anti-inflammatory drug with minimal gastric side effects has some selectivity for Cox-2 than Cox-1. In addition to inhibition of prostaglandin synthesis, It also reduces generation of superoxide by neutrophils, inhibits PAF synthesis, inhibits TNE and inhibits proteinase activity in cartilage, thus preventing breakdown of osteoarthritic human cartilage.

Indications

Osteoarthritis, dysmenorrhoea, rheumatoid, arthritis, low back pain, dysmenorrhoea, dental pain, post operative pain, trauma.

Contraindications

GI bleed, peptic ulcer, hepatic dysfunction, pregnancy, lactation.

Safety Profile

Reduce dose in elderly, renal dysfunction, heart failure.

Adverse Effects

Epigastralgia, heartburn, nausea, loose motions, rash, pruritus, somnolence, dizziness.

Dosage

100 mg twice a day. Children: 5 mg/kg/day in two or three divided dose.

Indications

Pain, fever

Contraindications

Analgesic nephropathy.

Safety Profile

Renal and hepatic impairment.

Adverse Effects

Epigastric distress, nausea, rashes, leukopenia is rare.

Dosage

Adults : 0.5-1.0gm. 3-6 times daily maximum 4gm.

Children : 15mg/kg/dose or 60 mg/kg/24 hours divided every 6 hours. Maximum 5 doses SOS (each dose -0-0 months – 40mg, 4-11 months -80mg, 1-6 years 120-240 mg., 6-12 years 220-480mg. Max. 5 doses/24 hours.