Description

Pipracillin 4 GM+ Tazobactum 500 MG

Piperacillin

This antipseudomonal penicillin is about 8 times more active than carbenicillin. It has good activity against Klebsiella and is used mainly in neutropenic/ immunocompromised patients having serious gram negative infections and in burns.

Indications

Pre Operative, gynaecological infections, urinary tract infections, respiratory tract infections, burns, septicaemia, systemic & local infections.

Contraindications

Hypersensitivity.

Safety Profile

Renal or hepatic insufficiency, high dose, prolonged use.

Adverse Effects

Platelet function disturbed cause bleeding, local pain, superinfections.

Drug Interactions

Efficiency of aminoglycosides decreased, muscle relaxant action of vecuronium increased.

Dosage

Adults 6-8 gm per day IU/IM severe and complicated infections: 112-18 gm per day.

Children: 25-75 / kg iv/im upto 6 hrs.

Tazobactam

Tazobactam inhibits beta lactamases. So the combination has broader spectrum of activity.

Indications

Appendicitis (complicated by rupture or abscess) and peritonitis, uncomplicated and complicated skin and structure infections, postpartum endometritis or pelvic inflammatory disease, community acquired pneumonia (moderate severity only), nosocomial pneumonia.

Contraindications

Hypersensitivity.

Adverse Effects

General: Rigors, back pain, malaise, (astenia, chest pain)

Dosage

Creatinine clearance (ml/min) :20-80: 12g/1.5g/ day in divided doses of 4.5 g every 8 hours.

Less than 20; 8g/1g/day in divided doses of 4.5 g every 12 hours.